Nardil and Periactin
Question:
Why not doxepin? It’s a stronger antihistimine and more sedative than Elavil.
doxepine is a much underused med for sure I prefer using it often to elavil as it is tolerated better-for most of my patients elavil is higher in sedation anticholinergic and antihistaminic activity-both sinequan and elavil are useable concomitantly with maoi’s and are basicaly interchangeable with a few caveats so you can switch from one to another without any significant problems so I often switch a patient from one to another when a greater boost of ad is needed-I have found ami to work a bit faster and have more punch but also more side effects that can be disruptive at first an aside regarding ap meds–I prefer to use risperdal over zyprexa for long term use it seems to have more reliability of activity whereas the zyprexa can loose its abilities after a year or so with psychotic or bipolar patients-zyprexa also tends to zone more seroqel has a wider range of therapeutic dosing which makes it more flexible but all can cause td as can phenothiazine cousins the tca’s and the so called selective meds like ssri’s-when you change brain chemistry you invariably affect dopamine regardless of its type or subtype and with this there is risk of neurological anomolies-years ago we discovered that statisticaly women on higher then average doses of first and second generation phenothiazines for protracted periods suffered td at much greater ratios-the newer so called novel meds being so much more potent then their older generations have drawbacks based upon their potency and so called selectivity or novel chemistry-I do not use these meds for panic disorders unless there is a valid specific indication for them-mellaril is a better crossover drug due to its lousy affinity to treating psychosis but a lousy anxiety med where benzos are first line abortive meds which is usualy the case-we can pretend to know great truths about the pharmicokinetics of these drugs but in reality we just take a shot with trial and error or empericism and clinical experience. Unlike more specific medical conditions that respond with more intrinsicaly reliable and reproducable effects psychiatry is often still in the dark ages of medicine-that’s why there is so much disagreement and strange brands of therapy like primal or emdr or regression etc..the educational experiences and the managed care mentality of most docs today is so compromised by a short sighted management as oppossed to sound clinical science that these practioners become dangerous-they overmedicate use the wrong meds make improper diagnosis LM
Response:
My sleep is still interrupted a bit and always thinking of tweaking with the Valium and/or taking Klonopin at bedtime. The key issue is not in my experience nardil is by nature a drug that imposes one level or another of insomnia and bedtime use usualy makes it worse-the half life of the drug is quick its actual cellular changes last long so early afternoon dosing seems to work for most-as for your valium 2-5 mg is low your doc can increase this up to a daily dose of 40mg if needed with the bulk at bedtime-problem is you may still have some sedation in the a.m..ask your doc about using a sedating
tca at Why not doxepin? It’s a stronger antihistimine and more sedative than Elavil. Matt – Hide quoted text — Show quoted text – bed with the nardil ie: elavil-this may also have enough antihistaminic activity for you as well-as for sexual enhancing effects of periactin its negligible-nardil is quite safe if your doc is experienced with using it also since your sleep is interupted it may be that a matter still of tweaking your dosing not of the nardil but the benzo primarily the time you take it-a late afternoon dose coupled by an evening and then a bed time one may work better then a single load. LM
Response:
My sleep is still interrupted a bit and always thinking of tweaking with the Valium and/or taking Klonopin at bedtime. The key issue is not
in my experience nardil is by nature a drug that imposes one level or another of insomnia and bedtime use usualy makes it worse-the half life of the drug is quick its actual cellular changes last long so early afternoon dosing seems to work for most-as for your valium 2-5 mg is low your doc can increase this up to a daily dose of 40mg if needed with the bulk at bedtime-problem is you may still have some sedation in the a.m..ask your doc about using a sedating tca at bed with the nardil ie: elavil-this may also have enough antihistaminic activity for you as well-as for sexual enhancing effects of periactin its negligible-nardil is quite safe if your doc is experienced with using it also since your sleep is interupted it may be that a matter still of tweaking your dosing not of the nardil but the benzo primarily the time you take it-a late afternoon dose coupled by an evening and then a bed time one may work better then a single load. LM
Response:
– Hide quoted text — Show quoted text – My sleep is still interrupted a bit and always thinking of tweaking with the Valium and/or taking Klonopin at bedtime. The key issue is not in my experience nardil is by nature a drug that imposes one level or another of insomnia and bedtime use usualy makes it worse-the half life of the drug is quick its actual cellular changes last long so early afternoon dosing seems to work for most-as for your valium 2-5 mg is low your doc can increase this up to a daily dose of 40mg if needed with the bulk at bedtime-problem is you may still have some sedation in the a.m..ask your doc about using a sedating tca at bed with the nardil ie: elavil-this may also have enough antihistaminic activity for you as well-as for sexual enhancing effects of periactin its negligible-nardil is quite safe if your doc is experienced with using it also since your sleep is interupted it may be that a matter still of tweaking your dosing not of the nardil but the benzo primarily the time you take it-a late afternoon dose coupled by an evening and then a bed time one may work better then a single load. LM
Thanks for the info…will try!! Before you buy.
Response:
Five weeks now on Nardil at doses ranging between 30mg to 60 mg. Practically every day has been trial and error with respect to the time of day to dose. It seems at this time that the least amount of side effects and disturbed sleep have come when taking the following meds at the following times: 30mg/45/60 at bedtime coupled with 4mg of Periactin(antihistamine)that works very very well for allergies(and allegedly for sex drive..but this has not been proven to me yet) and anywhere between 2-5 mg. of Valium. My sleep is still interrupted a bit and always thinking of tweaking with the Valium and/or taking Klonopin at bedtime. The key issue is not being too sedated the next morning or tired for good ol work. Would love to hear any and all experiences with those using Nardil and their experiences with DOSING AND BENZO USE. Thank you for your assisatance as always…the posts are often very helpful as experience tends to be the best teacher. Blu Before you buy.
