Glyburide
Question:
this is not really a reply to the queries about Glyburide, but another question. Specifically, I am taking 2.5 mg of glyburide each morning in an attempt to keep my bg under control. It seems to be effective. Will my body eventually become resistant to this dosage, and will I require more? or if I maintain my current regimen will things remain the same?
If we could answer this question, we might get nominated for a Nobel Prize. Many people have reported to this board that they’ve been able to stop oral medications after losing weight, beginning a program of regular exercise, and keeping their bg normal for several weeks or months. But whether it’ll happen for you this way is unpredictable. Diabetes is specific to each individual. So keep your fingers crossed. dkc David Cohler, South Pasadena, CA Media Access Consultancy http://members.tripod.com/~dcohler/
Response:
. Many people have reported to this board that they’ve been able to stop oral medications after losing weight, beginning a program of regular exercise, and keeping their bg normal for several weeks or months. But whether it’ll happen for you this way is unpredictable. Diabetes is specific to each individual. So keep your fingers crossed. While emphasizing that I may be the exception rather than the rule, let
me report that I am one of those that Dave referred to. Was diagnosed in March 95 with a 480 mg/dl (plasma) and a 17.6 a1c. Was started on very heavy glyburide dosage (22.5 mg/day). As I lost weight and continued to watch my carbos over the ensuing 11 months, they kept backing the dosage down until my endo took me off all meds 11 months later. My last 2 a1c readings were 5.2. While still on meds I even did a 4.7. Exercise?? Only what working as a computer specialist and living the life of a suburban home owner entails. I don’t believe in self abuse. My weight leveled off at the beginning of this year and I have kept it within 2 lbs of that line ever since. Once again, I would rather stay with this positive account but everybody’s reaction this monster is different. I can only hope that your system responds as mine did. Whatever it is in my system, I wish I could bottle it and give it to everyone else. I know it sounds trite, but think positive. Let’s assume that my experience is the rule rather than the exception. That, at least, puts the odds in your favor. S. F. – Hide quoted text — Show quoted text – David Cohler, South Pasadena, CA Media Access Consultancy http://members.tripod.com/~dcohler/
Response:
this is not really a reply to the queries about Glyburide, but another question. Specifically, I am taking 2.5 mg of glyburide each morning in an attempt to keep my bg under control. It seems to be effective. Will my body eventually become resistant to this dosage, and will I require more? or if I maintain my current regimen will things remain the same? Thanks in advance, Al O
Response:
warning on the prescription in Canada. I’m writing to ask you if the warning statement is correct and also whether Glyburide is still prescribed for diabetics? Thanking you in anticipation of an The answer is both yes and no. There is an increased risk, My understanding is that it’s very slight, but it’s still there. The pharmicutical industry here in the United states is quite understandably parinoid so they warn against any danger real or imagined no matter how slight the risk. The problem with this is that the warnings are self defeting. Americans get so "hardened" to the warnings that they ignore them and die anyway saying "Why didn’t somebody warn me" Often their faimly asks that in a court of law, So the drug stores (Usually) have a large collection of warning labels they slap and they find one or two for just about every prescription they fill. Buy a glass of water in a drug store and it’s likely to have a label "Caution… May cause drowning" "Nothing adds excitement like something that is none of your business" Never MOON a werewolf Net-Tamer V 1.07X; Beta – Registered
Response:
this is not really a reply to the queries about Glyburide, but another question. Specifically, I am taking 2.5 mg of glyburide each morning in an attempt to keep my bg under control. It seems to be effective. Will my body eventually become resistant to this dosage, and will I require more? or if I maintain my current regimen will things remain the same?
The answers in order are maybe, maybe, and maybe. It is not unusual for sulfonylureas loose effectivness within 5 years, but it is not universal. Some people even require less as their diet and exercise regimens improve. There is no way to predict the course of an individual case. — Charles Coughran
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I use it here in the USA and have never seen such a warning. I heard from a friend that Glyburide (when purchased in the U.S. of A)
has a warning label on the bottle stating that there is an increased risk of cardiovascular mortality.
Response:
I heard from a friend that Glyburide (when purchased in the U.S. of A) has a warning label on the bottle stating that there is an increased risk of cardiovascular mortality. There is no such warning on the prescription in Canada. I’m writing to ask you if the warning statement is correct and <snip
According to Dr. Whitaker, who wrote ‘Reversing Diabetes’ there is an increased risk of cardiovascular problems with some of the oral med- ications for diabetes. George Davis, IDDM, MI, 32yrs
Response:
I heard from a friend that Glyburide (when purchased in the U.S. of A) has a warning label on the bottle stating that there is an increased risk of cardiovascular mortality. There is no such warning on the prescription in Canada. I’m writing to ask you if the warning statement is correct and also whether Glyburide is still prescribed for diabetics? Thanking you in anticipation of an early reply. Sincerely, Colin Marsh
The warning is in the aftermath of a study UGDP, early 1970’s) done many years ago that seemed to link the use of Oral hypoglycemic agents (tolbutamide I believe) with increased cardiovascular risks. Subsequent examination of the study revealed some fairly serious problem with the patient selection, and other mechanics of the study. The end result is at this point, most people don’t think much of the conclussions drawn from the study. At best they are suspect. The reported increase in risk was 2.5 times the non-treated group. The big problem with the study is the ones treated by diet alone tended to have few cardiovascular risks to begin with (i.e. they probably were not as overweight), and no effort was made to match patients treated with Tolbutamide to similar age, height, and weight patients not taking the drug. Consequently the test was not well controlled. To avoid potential litigation, however the drug company’s continue to report the study, although the PDR points out ‘the controversy regarding interpretation of these results’.. The bottom line is that isn’t clear that the results of the study are ‘real’.
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The PDR I think I remember seeing the caution in was a pre 1985 PDR. Clarence Wilkerson
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I am using 5MG/day and it seems to be having some positive effect. The fact sheet I got from my pharmacy very recently still warns of the risk of increased cardiac mortality. Ibelieve this is a pro-forma requirement. I have seen nothing that indicates a need for any special concern. Howard Cherney, Tamarac, FL
Response:
My memory is the warning goes back to a small study in the late 70’s camparing patients with Glyburide treatment alone to patients with a diet/execise regimen. I believe the PDR has some reference to this point. I don’t think the higher mortality rate for the Glyburide has been verified in any later studies. But one could easily believe that a diet/execise regimen in addition to Glyburide treatment would be helpful. The usual warnings apply to this recall! Clarence Wilkerson
Response:
(Clarence Wilkerson) writes: My memory is the warning goes back to a small study in the late 70’s camparing patients with Glyburide treatment alone to patients with a diet/execise regimen. I believe the PDR has some reference to this point.
The 1997 edition of the PDR is out, and checking therein, I find no reference of this nature. I don’t think the higher mortality rate for the Glyburide has been verified in any later studies. But one could easily believe that a diet/execise regimen in addition to Glyburide treatment would be helpful.
Diet and exercise are known to be beneficial to diabetics and non-diabetics alike, and to diabetics whether or not they’re using Glyburide. Bill Mayers, RT, RN
Response:
I heard from a friend that Glyburide (when purchased in the U.S. of A) has a warning label on the bottle stating that there is an increased risk of cardiovascular mortality. There is no such warning on the prescription in Canada. I’m writing to ask you if the warning statement is correct and also whether Glyburide is still prescribed for diabetics? Thanking you in anticipation of an early reply. Sincerely, Colin Marsh
Glyburide also does not carry such a warning here in the US, because such a warning is not necessary. Glyburide does carry some small risk, and that’s mostly when it is used along with other prescription drugs with which there’s the possiblity of interaction. Pharmacists and physicians are expected to be aware of these possible interactions, and to properly monitor patients who might be using these drugs together. Bill Mayers, RT, RN
Response:
I heard from a friend that Glyburide (when purchased in the U.S. of A) has a warning label on the bottle stating that there is an increased risk of cardiovascular mortality. There is no such warning on the prescription in Canada. I’m writing to ask you if the warning statement is correct and also whether Glyburide is still prescribed for diabetics? Thanking you in anticipation of an early reply. Sincerely, Colin Marsh
Actually there is a risk. The big problem would be from an overdose which would induce insulin shock and death. However, according to my doctor, there is minimum risk is taken properly. Oh yes, the same disclaimer appears on all insulin substitute pills suh as micronaise etc. Don’t worry. So little time to do So MUCH
Response:
I heard from a friend that Glyburide (when purchased in the U.S. of A) has a warning label on the bottle stating that there is an increased risk of cardiovascular mortality. There is no such warning on the prescription in Canada. I’m writing to ask you if the warning statement is correct and also whether Glyburide is still prescribed for diabetics? Thanking you in anticipation of an early reply. Sincerely, Colin Marsh
Response:
That might be true for OSA sufferers that develop type 1 DM, but what about insulin resistant type 2 diabetics that have excess insulin produced by the pancreas? All the studies I’ve seen have not hypothesized a reason for the realtionship, they just point out the very high correlation between the two disorders. Also, studies usually point out that both are linked to obesity even though there are thin people that have either DM, OSA or both. I think a more common reason for the link is probably that after getting sleep apnea most people become markedly less active and therefore stop exercising and sports participation. They then lose the metabolism benefits of exercise which may have kept their DM undetectable. BigAl – Hide quoted text — Show quoted text – snipped < Sorry, I belive it is the otherway arround, Apnea contributes to getting diabetes. The oxugen deprivation that sleep apnea can cause injury to organs of the body, this include the pancreas, thryoid, brain, heart, etc) snipped<
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I think we also need to take into account that most people with sleep apnea are also overweight which is also linked with developing type II diabetes. Losing the excess poundage can often aid in the sleep apnea problem, as it also does with type II diabetes. Anyone able to expand on this further through personal experience? Peg — I’m an American. I used to live in England. Now I’m back! remove "ANTISPAM" from my email address – Hide quoted text — Show quoted text – That might be true for OSA sufferers that develop type 1 DM, but what about insulin resistant type 2 diabetics that have excess insulin produced by the pancreas? All the studies I’ve seen have not hypothesized a reason for the realtionship, they just point out the very high correlation between the two disorders. Also, studies usually point out that both are linked to obesity even though there are thin people that have either DM, OSA or both. I think a more common reason for the link is probably that after getting sleep apnea most people become markedly less active and therefore stop exercising and sports participation. They then lose the metabolism benefits of exercise which may have kept their DM undetectable. BigAl snipped < Sorry, I belive it is the otherway arround, Apnea contributes to getting diabetes. The oxugen deprivation that sleep apnea can cause injury to organs of the body, this include the pancreas, thryoid, brain, heart, etc) snipped<
Response:
I have sleep apnea.. I have a CPAP pump and mask that I wear at night. It blows a column of air that lets me sleep without the problems. First night I used it, it felt strange, but I was amazed at what it felt like to get a good night’s sleep. My wife has a bi-pap machine, which works with inhalation and exhalation…
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With a BMI of 39, you are insulin resistant. Even if you take insulin it might not work any better to lower your bg’s. I have been there before also. I have lost 70 lbs. I was on 60 units NPH and now I don’t need any sincerly,yours Arnold
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- Hide quoted text — Show quoted text – Hi. I have recently been diagnosed with Type II diabetes. My doctor has given me Glyburide and I take that 2 times a day. I am also taking Synthroid for my hypothyroid. My blood surgars are usually around 190. I am a 21 year old. I am overweight. BMI about 39. I am on a 2000 calorie diet. I exercise 1/2 hour day vigurously walking. Some of the problems I’ve been having. Fatigue unable to concentrate depressed alot. etc. Some of these i’ve had before I was ever diagnosed with Diabetes. Does this sound like I either need to switch medication or be put on insulin. My sister has Type I. My doctor see’s me once every 3 months for checkups.
Severe fatigue was my primary symptom and started about a year before I was diagnosed. It is mostly gone now that my bg is in the normal range. Try to forget the symtoms and concentrate on lowering your blood sugar. It took me a couple of months to get my bg low enough to make me feel better. Also, do you have any problems sleeping? Your problems are also indicative of Obstructive Sleep Apnea. I have both. OSA was diagnosed years before diabetes. Since for me they have many of the same symptoms, the diabetes diagnosis was delayed. It might be worth checking out. — BigAl
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What do you do about the sleep apnea. Do you take any medications? I don’t sleep well and many mornings feel like s–t due to laying awake much of the night. I had this well before the diabetes. Now its worse, because on really restless nights bg seems higher.
Response:
What do you do about the sleep apnea. Do you take any medications? I don’t sleep well and many mornings feel like s–t due to laying awake much of the night. I had this well before the diabetes. Now its worse, because on really restless nights bg seems higher.
Not to get into details, but there are 2 types of sleep apnea. Apnea is a cessationm of breathing while sleeping. For the obstructive type you sleep with a mask that feeds slightly pressurized air through your nose to keep your airway open. There are also a lot of other sleep disorders. I mentiones OSA specifically because studies have shown a higher than normal incidence in people with diabetes. The FAQ is at http://www.newtechpub.com/phantom/faq/osa_faq.htm If you want more information after reading the FAQ email me or go to alt.support.sleep-disorder and post there. — BigAl
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| | What do you do about the sleep apnea. Do you take any medications? I | don’t sleep well and many mornings feel like s–t due to laying awake | much of the night. I had this well before the diabetes. Now its worse, | because on really restless nights bg seems higher. | | Not to get into details, but there are 2 types of sleep apnea. Apnea is | a cessationm of breathing while sleeping. For the obstructive type you | sleep with a mask that feeds slightly pressurized air through your nose | to keep your airway open. There are also a lot of other sleep | disorders. I mentiones OSA specifically because studies have shown a | higher than normal incidence in people with diabetes. The FAQ is at | http://www.newtechpub.com/phantom/faq/osa_faq.htm If you want more | information after reading the FAQ email me or go to | alt.support.sleep-disorder and post there. Sorry, I belive it is the otherway arround, Apnea contributes to getting diabetes. The oxugen deprivation that sleep apnea can cause injury to organs of the body, this include the pancreas, thryoid, brain, heart, etc) — Siemens Power System Control Phone: (612)-536-4403 FAX : (612)-536-4947
Response:
I think we also need to take into account that most people with sleep apnea are also overweight which is also linked with developing type II diabetes. Losing the excess poundage can often aid in the sleep apnea problem, as it also does with type II diabetes. Anyone able to expand on this further through personal experience? Peg
I am type II with OSA..(Obstuctive sleep Apnea). What I found, was that the sleep disorder had me eating frequently during the day, to give me an energy "boost". Towards the end, it was alot of sugary stuff. When you’re REALLY TIRED you eat alot of sugar, to give you a lift. Since you are sleep deprived, your metabolism slows down anyway, and you have no energy to exercise. This packs on the pounds, and can trigger a DM type II problem, at least in my understanding of the two disorders, anyway. At any rate, the diabetes confused the issue. I felt so tired and miserable from the DM, that we thought the Apnea treatment wasn’t effective. What a crummy hamster wheel. It’s all straighteded out now though. It’s great to fell GOOD
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Had good stuff on Glucophage in the last few lots of messages, could we have some thoughts on Glyburide, please. Am on 1500 Metformin and 10 mg Glyburide each day Type II 3 years bypass(3) 2 years.
Glyburide acts by stimulating the beta cells of the pancreas to produce additional endogenous insulin. It has no other appreciable effect. The maximum recommended dosage is 20 mg/day. The maximum for Glucophage is 2550/day, so you have a little room left. As you age the condition tends to worsen, requiring increases in therapy to keep the BG’s in control. Most endocrinologists today are giving glyburide a second look. It has long been the standard therapy for Type 2 diabetics. The problem is that recent experience suggests that excessive and continuous stimulation of the beta cells poops them out. In other words, the glyburide may actually be making your condition worse. Of course, if you’re old enough that you’re not likely to live long enough to matter, then there’s no need for concern. However, many endo’s are no recommending switching from glyburide to insulin. I.e., instead of beating up your poor beta cells, why not add exogenous insulin and reduce the load on them? In your case, the doc would probably keep the Glucophage, since it does not stimulate additional insulin production. Each person is different, so your doc may have excellent reasons for continuing your current therapy. I mention this only as something for you to consider. NOTICE: The e-mail address is deliberately incorrect. Make the ISP read "nwpacifica.net" by adding a "w."
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Had good stuff on Glucophage in the last few lots of messages, could we have some thoughts on Glyburide, please. Am on 1500 Metformin and 10 mg Glyburide each day Type II 3 years bypass(3) 2 years. I don’t have any sales figures to back this up, but I would guess that glyburide is the most popular of the sulfanylurea drugs. The only first-generation SU that seems to be mentioned much around here is Diabinese. Among the second-generation SUs, there is glipizide (glucotrol) which is popular, and amaryl, but there are three major brands of glyburide – micronase, diabeta, and glynase. That’s a relatively high dose of glucophage, not too high a dose of glyburide. Some doctors are reluctant to give glucophage to people who’ve had heart or liver damage; I hope he’s doing liver function tests regularly. Otherwise, it sounds like your doctor is trying to minimize hyperinsulinism. He’s probably very good or very bad. <grin The differences in the second-generation SUs are mostly in price and in side-effects. And because there are so *many* different disorders that get diagnosed as Type 2 diabetes, YMMV – your milage may vary. Until recently, the SUs were about all there was in the way of meds to treat Type 2 diabetes. They mostly goose the pancreas into giving up insulin. Most Type 2s, the problem mostly is that insulin doesn’t get used very effectively by the body. It does bring down the BGs to add still more insulin, but insulin is a powerful hormone that does harm as well as good. The approach of "well, if it doesn’t fit, just get a bigger hammer" is a little more acceptable with a car you can trade in than with a body you’re stuck with. How are your BGs running? —- GenerousCity is a virtue. Why pay $9.95/month? Search the profiles of fun singles, talk on the GenerousSingles list, or join us for live chat. http://generous.net
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Had good stuff on Glucophage in the last few lots of messages, could we have some thoughts on Glyburide, please. Am on 1500 Metformin and 10 mg Glyburide each day Type II 3 years bypass(3) 2 years. Frank
