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	<title>Sleeping Disorder &#187; Shift Work Sleep Disorder</title>
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		<title>Another Paxil Question For Jackie (and anyone else with advice)</title>
		<link>http://sleepingdisorderfaq.com/shift-work-sleep-disorder/another-paxil-question-for-jackie-and-anyone-else-with-advice-2075318.html</link>
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		<pubDate>Tue, 03 May 2005 00:00:00 +0000</pubDate>
		<dc:creator>admin</dc:creator>
				<category><![CDATA[Shift Work Sleep Disorder]]></category>

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		<description><![CDATA[Question:
 ::Thanks so much for your informative response.  You are welcome    ::I&#8217;m glad you mentioned that Wellbutrin can be a problem for people with  ::anxiety. I do suffer from GAD. I had to take xanax for quite a while&#44;  ::but have been off it for several months and the [...]]]></description>
			<content:encoded><![CDATA[<h4><strong>Question:</strong></h4>
<p> ::Thanks so much for your informative response.  You are welcome <img src='http://sleepingdisorderfaq.com/wp-includes/images/smilies/icon_smile.gif' alt=':)' class='wp-smiley' />   ::I&#8217;m glad you mentioned that Wellbutrin can be a problem for people with  ::anxiety. I do suffer from GAD. I had to take xanax for quite a while&#44;  ::but have been off it for several months and the Paxil CR I used to take  ::seemed to handle the anxiety pretty well. It&#8217;s only when I had to switch  ::to regular Paxil that I started having problems. BTW&#44; have you heard  ::when Paxil CR might be available again?  I went to drugstore.com and it seems that paxil cr is available. I was able to  add paxil cr to my shopping cart without getting a notice that it was  unavailable. Call a local pharmacy and inquire about paxil cr`s status.  http://www.drugstore.com/pharmacy/drugindex/rxsearch.asp?search=paxil+cr  Good luck with your upcoming pdoc appt! Let me know how it goes.  Jackie  ~*~I`m an angel! Honest <img src='http://sleepingdisorderfaq.com/wp-includes/images/smilies/icon_smile.gif' alt=':)' class='wp-smiley' />  The horns are just there to keep my halo up  straight~*~  &#8212;  The charter is available at: http://readystump.algebra.com/~asapm </p>
</p>
<h4><strong>Response:</strong></h4>
<p>   Hello Jackie:   A while back&#44; you were very helpful and answered a question for me about   the sedating effects of Paxil. I was now wondering whether Paxil can   ever cause dizziness. I occasionally feel just slightly dizzy when I   stand up and when I&#8217;m walking. I&#8217;m wondering whether you&#8217;ve experienced   anything similar.   Also&#44; in your prior response&#44; you mentioned that Wellbutrin might help   me offset the sedating effect of the Paxil. Since I&#8217;ll be seeing my   psychiatrist in a few days&#44; I was hoping to get your thoughts on the   right dosage for Wellbutrin and on any other meds that help offset the   sedation. </p>
<p>I&#8217;d change to a less sedating SSRI&#44; such as Zoloft&#44; Celexa&#44; or Lexapro. Then  you wouldn&#8217;t have to take two pills.  Chip  &#8212;  The charter is available at: http://readystump.algebra.com/~asapm </p>
</p>
<h4><strong>Response:</strong></h4>
<p>Jackie:  I checked with my regular pharmacist. He said that CR is not yet  available and no date has been announced. I wonder if you&#8217;ll get a  notice from Drugstore.com that it made a mistake. Thanks again.  DCH  &#8211; Hide quoted text &#8212; Show quoted text &#8211;  ::Thanks so much for your informative response.   You are welcome <img src='http://sleepingdisorderfaq.com/wp-includes/images/smilies/icon_smile.gif' alt=':)' class='wp-smiley' />    ::I&#8217;m glad you mentioned that Wellbutrin can be a problem for people with   ::anxiety. I do suffer from GAD. I had to take xanax for quite a while&#44;   ::but have been off it for several months and the Paxil CR I used to take   ::seemed to handle the anxiety pretty well. It&#8217;s only when I had to switch   ::to regular Paxil that I started having problems. BTW&#44; have you heard   ::when Paxil CR might be available again?   I went to drugstore.com and it seems that paxil cr is available. I was able to   add paxil cr to my shopping cart without getting a notice that it was   unavailable. Call a local pharmacy and inquire about paxil cr`s status.   http://www.drugstore.com/pharmacy/drugindex/rxsearch.asp?search=paxil+cr   Good luck with your upcoming pdoc appt! Let me know how it goes.   Jackie   ~*~I`m an angel! Honest <img src='http://sleepingdisorderfaq.com/wp-includes/images/smilies/icon_smile.gif' alt=':)' class='wp-smiley' />  The horns are just there to keep my halo up   straight~*~ </p>
<p>&#8211;  The charter is available at: http://readystump.algebra.com/~asapm </p>
</p>
<h4><strong>Response:</strong></h4>
<p>Chip:  Thanks for your help. I have an appointment with my psychiatrist  tomorrow afternoon and I&#8217;ll mention your suggestions.  DCH  &#8211; Hide quoted text &#8212; Show quoted text &#8211; Hello Jackie:  A while back&#44; you were very helpful and answered a question for me about  the sedating effects of Paxil. I was now wondering whether Paxil can  ever cause dizziness. I occasionally feel just slightly dizzy when I  stand up and when I&#8217;m walking. I&#8217;m wondering whether you&#8217;ve experienced  anything similar.  Also&#44; in your prior response&#44; you mentioned that Wellbutrin might help  me offset the sedating effect of the Paxil. Since I&#8217;ll be seeing my  psychiatrist in a few days&#44; I was hoping to get your thoughts on the  right dosage for Wellbutrin and on any other meds that help offset the  sedation.   I&#8217;d change to a less sedating SSRI&#44; such as Zoloft&#44; Celexa&#44; or Lexapro. Then   you wouldn&#8217;t have to take two pills.   Chip </p>
<p>&#8211;  The charter is available at: http://readystump.algebra.com/~asapm </p>
</p>
<h4><strong>Response:</strong></h4>
<p>Hello Jackie:  A while back&#44; you were very helpful and answered a question for me about  the sedating effects of Paxil. I was now wondering whether Paxil can  ever cause dizziness. I occasionally feel just slightly dizzy when I  stand up and when I&#8217;m walking. I&#8217;m wondering whether you&#8217;ve experienced  anything similar.  Also&#44; in your prior response&#44; you mentioned that Wellbutrin might help  me offset the sedating effect of the Paxil. Since I&#8217;ll be seeing my  psychiatrist in a few days&#44; I was hoping to get your thoughts on the  right dosage for Wellbutrin and on any other meds that help offset the  sedation.  Thanks in advance&#44;  DCH  &#8212;  The charter is available at: http://readystump.algebra.com/~asapm </p>
</p>
<h4><strong>Response:</strong></h4>
<p> ::A while back&#44; you were very helpful and answered a question for me about  ::the sedating effects of Paxil. I was now wondering whether Paxil can  ::ever cause dizziness. I occasionally feel just slightly dizzy when I  ::stand up and when I&#8217;m walking. I&#8217;m wondering whether you&#8217;ve experienced  ::anything similar.  ::  ::Also&#44; in your prior response&#44; you mentioned that Wellbutrin might help  ::me offset the sedating effect of the Paxil. Since I&#8217;ll be seeing my  ::psychiatrist in a few days&#44; I was hoping to get your thoughts on the  ::right dosage for Wellbutrin and on any other meds that help offset the  ::sedation.  ::  ::Thanks in advance&#44;  Helloooo DCH <img src='http://sleepingdisorderfaq.com/wp-includes/images/smilies/icon_smile.gif' alt=':)' class='wp-smiley' />   Yes&#44; paxil can cause dizziness. It`s one of the most common side-effects. One of  the pharmacies I used to fill my paxil script a few years back use to put a  warning label on my paxil body about needing to change positions slowly. What  happens is when you change positions quickly&#44; like from laying down or sitting&#44;  to a standing position&#44; your blood pressure drops a bit and you get lightheaded  or dizzy. Google orthostatic hypotension to learn more about it if you like.  This still happens to me&#44; annoying but not dangerous. Try to change your  positions slowly. Go to a sitting position and dangle first before standing&#44; if  you had been laying down. That should help.  About the wellbutrin&#8230;&#8230;.your pdoc will know best what dose to start you at&#44;  if he even chooses wellbutrin. I would say start with the absolute lowest and  see if that helps. Keep in mind that wellbutrin is a stimulating antidepressant  and many people with anxiety cannot tolerate it. Of course&#44; there are always  exceptions to the rules.Paxil sedation still a problem for you? How is it  working otherwise? Take care <img src='http://sleepingdisorderfaq.com/wp-includes/images/smilies/icon_smile.gif' alt=':)' class='wp-smiley' />   Jackie  ~*~I`m an angel! Honest <img src='http://sleepingdisorderfaq.com/wp-includes/images/smilies/icon_smile.gif' alt=':)' class='wp-smiley' />  The horns are just there to keep my halo up  straight~*~  &#8212;  The charter is available at: http://readystump.algebra.com/~asapm </p>
</p>
<h4><strong>Response:</strong></h4>
<p>Jackie:  Thanks so much for your informative response.  I am still having a problem with sedation. I don&#8217;t feel physically weak&#44;  but do feel like I haven&#8217;t had enough sleep. I do get 6 to 8 hours sleep  a night so I don&#8217;t think that is a problem.  I&#8217;m glad you mentioned that Wellbutrin can be a problem for people with  anxiety. I do suffer from GAD. I had to take xanax for quite a while&#44;  but have been off it for several months and the Paxil CR I used to take  seemed to handle the anxiety pretty well. It&#8217;s only when I had to switch  to regular Paxil that I started having problems. BTW&#44; have you heard  when Paxil CR might be available again?  DCH  &#8211; Hide quoted text &#8212; Show quoted text &#8211;  ::A while back&#44; you were very helpful and answered a question for me about   ::the sedating effects of Paxil. I was now wondering whether Paxil can   ::ever cause dizziness. I occasionally feel just slightly dizzy when I   ::stand up and when I&#8217;m walking. I&#8217;m wondering whether you&#8217;ve experienced   ::anything similar.   ::   ::Also&#44; in your prior response&#44; you mentioned that Wellbutrin might help   ::me offset the sedating effect of the Paxil. Since I&#8217;ll be seeing my   ::psychiatrist in a few days&#44; I was hoping to get your thoughts on the   ::right dosage for Wellbutrin and on any other meds that help offset the   ::sedation.   ::   ::Thanks in advance&#44;   Helloooo DCH <img src='http://sleepingdisorderfaq.com/wp-includes/images/smilies/icon_smile.gif' alt=':)' class='wp-smiley' />    Yes&#44; paxil can cause dizziness. It`s one of the most common side-effects. One of   the pharmacies I used to fill my paxil script a few years back use to put a   warning label on my paxil body about needing to change positions slowly. What   happens is when you change positions quickly&#44; like from laying down or sitting&#44;   to a standing position&#44; your blood pressure drops a bit and you get lightheaded   or dizzy. Google orthostatic hypotension to learn more about it if you like.   This still happens to me&#44; annoying but not dangerous. Try to change your   positions slowly. Go to a sitting position and dangle first before standing&#44; if   you had been laying down. That should help.   About the wellbutrin&#8230;&#8230;.your pdoc will know best what dose to start you at&#44;   if he even chooses wellbutrin. I would say start with the absolute lowest and   see if that helps. Keep in mind that wellbutrin is a stimulating antidepressant   and many people with anxiety cannot tolerate it. Of course&#44; there are always   exceptions to the rules.Paxil sedation still a problem for you? How is it   working otherwise? Take care <img src='http://sleepingdisorderfaq.com/wp-includes/images/smilies/icon_smile.gif' alt=':)' class='wp-smiley' />    Jackie   ~*~I`m an angel! Honest <img src='http://sleepingdisorderfaq.com/wp-includes/images/smilies/icon_smile.gif' alt=':)' class='wp-smiley' />  The horns are just there to keep my halo up   straight~*~ </p>
<p>&#8211;  The charter is available at: http://readystump.algebra.com/~asapm </p>
</p>
<h4><strong>Response:</strong></h4>
<p>  ::I saw my psychiatrist yesterday afternoon. In order to control the </p>
<p>Jackie:  My psychiatrist told me that a number of his patients have successfully  used Provigil. Hopefully&#44; just taking the Paxil in the evening will do  the trick&#44; however. I&#8217;ll let you know what happens.  &#8211; DCH  &#8211; Hide quoted text &#8212; Show quoted text &#8211; ::sleepiness&#44; he asked me to take my whole Paxil dosage before going to   ::bed instead of half in the morning and half in the evening. If that   ::doesn&#8217;t resolve the problem after a few days&#44; he wants me to try taking   ::100 mg of Provigil C when I get up in the morning. According to my   ::psychiatrist&#44; this drug is used to treat narcolepsy (at much higher   ::doses) and shift work sleep disorder. He also said that it will not   ::increase anxiety. If necessary&#44; I can also take an additional 100 mg at   ::noon. At least I didn&#8217;t have to pay for the Provigil since he had   ::samples in his office. I&#8217;ll let you know how things are going after a   ::few days. If you&#8217;re interested in reading more about Provigil&#44; here&#8217;s a   ::link to the Mayo Clinic&#8217;s description of the med.   Dear DCH&#44;   I hope taking the paxil in the PM works for you! Just beware that some people&#44;   like me&lt;g&#44; can`t tolerate taking antidepressants in the evening. Strange as it   sounds&#44; taking paxil in the AM makes me feel tired&#8230;..but when I took it in the   PM&#44; it made me feel so restless that I had a hard time sleeping. This doesn`t   About provigil&#44; from everything I read about it&#44; it seems there are better   choices out there. You might want to browse through some archived posts on   provigil.   http://makeashorterlink.com/?R2BA1280B   Good luck! I hope you find an answer for the paxil fatigue <img src='http://sleepingdisorderfaq.com/wp-includes/images/smilies/icon_smile.gif' alt=':)' class='wp-smiley' />    Jackie   ~*~Anything preying on my mind would starve to death~*~ </p>
<p>&#8211;  The charter is available at: http://readystump.algebra.com/~asapm </p>
</p>
<h4><strong>Response:</strong></h4>
<p>Hi&#44; DH&#44;  Best wishes with the med adjustment. &nbsp;Keep us updated on how it&#8217;s going for  you.  smiles&#44;  Elise </p>
<p> &#8211; Hide quoted text &#8212; Show quoted text &#8211; Hi Jacqueline:   I saw my psychiatrist yesterday afternoon. In order to control the   sleepiness&#44; he asked me to take my whole Paxil dosage before going to   bed instead of half in the morning and half in the evening. If that   doesn&#8217;t resolve the problem after a few days&#44; he wants me to try taking   100 mg of Provigil C when I get up in the morning. According to my   psychiatrist&#44; this drug is used to treat narcolepsy (at much higher   doses) and shift work sleep disorder. He also said that it will not   increase anxiety. If necessary&#44; I can also take an additional 100 mg at   noon. At least I didn&#8217;t have to pay for the Provigil since he had   samples in his office. I&#8217;ll let you know how things are going after a   few days. If you&#8217;re interested in reading more about Provigil&#44; here&#8217;s a   link to the Mayo Clinic&#8217;s description of the med. </p>
<p>http://www.mayoclinic.com/invoke.cfm?objectid=3361ACED-6F3F-49BD-A92E&#8230;  &#8211; Hide quoted text &#8212; Show quoted text &#8211; Thanks again for your help.   &#8211; DCH    ::Thanks so much for your informative response.    You are welcome <img src='http://sleepingdisorderfaq.com/wp-includes/images/smilies/icon_smile.gif' alt=':)' class='wp-smiley' />     ::I&#8217;m glad you mentioned that Wellbutrin can be a problem for people  with    ::anxiety. I do suffer from GAD. I had to take xanax for quite a while&#44;    ::but have been off it for several months and the Paxil CR I used to  take    ::seemed to handle the anxiety pretty well. It&#8217;s only when I had to  switch    ::to regular Paxil that I started having problems. BTW&#44; have you heard    ::when Paxil CR might be available again?    I went to drugstore.com and it seems that paxil cr is available. I was  able to    add paxil cr to my shopping cart without getting a notice that it was    unavailable. Call a local pharmacy and inquire about paxil cr`s status.    http://www.drugstore.com/pharmacy/drugindex/rxsearch.asp?search=paxil+cr    Good luck with your upcoming pdoc appt! Let me know how it goes.    Jackie    ~*~I`m an angel! Honest <img src='http://sleepingdisorderfaq.com/wp-includes/images/smilies/icon_smile.gif' alt=':)' class='wp-smiley' />  The horns are just there to keep my halo up    straight~*~   &#8212;   The charter is available at: http://readystump.algebra.com/~asapm </p>
<p>&#8211;  The charter is available at: http://readystump.algebra.com/~asapm </p>
</p>
<h4><strong>Response:</strong></h4>
<p> ::I saw my psychiatrist yesterday afternoon. In order to control the  ::sleepiness&#44; he asked me to take my whole Paxil dosage before going to  ::bed instead of half in the morning and half in the evening. If that  ::doesn&#8217;t resolve the problem after a few days&#44; he wants me to try taking  ::100 mg of Provigil C when I get up in the morning. According to my  ::psychiatrist&#44; this drug is used to treat narcolepsy (at much higher  ::doses) and shift work sleep disorder. He also said that it will not  ::increase anxiety. If necessary&#44; I can also take an additional 100 mg at  ::noon. At least I didn&#8217;t have to pay for the Provigil since he had  ::samples in his office. I&#8217;ll let you know how things are going after a  ::few days. If you&#8217;re interested in reading more about Provigil&#44; here&#8217;s a  ::link to the Mayo Clinic&#8217;s description of the med.  Dear DCH&#44;  I hope taking the paxil in the PM works for you! Just beware that some people&#44;  like me&lt;g&#44; can`t tolerate taking antidepressants in the evening. Strange as it  sounds&#44; taking paxil in the AM makes me feel tired&#8230;..but when I took it in the  PM&#44; it made me feel so restless that I had a hard time sleeping. This doesn`t  About provigil&#44; from everything I read about it&#44; it seems there are better  choices out there. You might want to browse through some archived posts on  provigil.  http://makeashorterlink.com/?R2BA1280B  Good luck! I hope you find an answer for the paxil fatigue <img src='http://sleepingdisorderfaq.com/wp-includes/images/smilies/icon_smile.gif' alt=':)' class='wp-smiley' />   Jackie  ~*~Anything preying on my mind would starve to death~*~  &#8212;  The charter is available at: http://readystump.algebra.com/~asapm </p>
</p>
<h4><strong>Response:</strong></h4>
<p>Hi Jacqueline:  I saw my psychiatrist yesterday afternoon. In order to control the  sleepiness&#44; he asked me to take my whole Paxil dosage before going to  bed instead of half in the morning and half in the evening. If that  doesn&#8217;t resolve the problem after a few days&#44; he wants me to try taking  100 mg of Provigil C when I get up in the morning. According to my  psychiatrist&#44; this drug is used to treat narcolepsy (at much higher  doses) and shift work sleep disorder. He also said that it will not  increase anxiety. If necessary&#44; I can also take an additional 100 mg at  noon. At least I didn&#8217;t have to pay for the Provigil since he had  samples in his office. I&#8217;ll let you know how things are going after a  few days. If you&#8217;re interested in reading more about Provigil&#44; here&#8217;s a  link to the Mayo Clinic&#8217;s description of the med.  http://www.mayoclinic.com/invoke.cfm?objectid=3361ACED-6F3F-49BD-A92E&#8230;  Thanks again for your help.  &#8211; DCH  &#8211; Hide quoted text &#8212; Show quoted text &#8211;  ::Thanks so much for your informative response.   You are welcome <img src='http://sleepingdisorderfaq.com/wp-includes/images/smilies/icon_smile.gif' alt=':)' class='wp-smiley' />    ::I&#8217;m glad you mentioned that Wellbutrin can be a problem for people with   ::anxiety. I do suffer from GAD. I had to take xanax for quite a while&#44;   ::but have been off it for several months and the Paxil CR I used to take   ::seemed to handle the anxiety pretty well. It&#8217;s only when I had to switch   ::to regular Paxil that I started having problems. BTW&#44; have you heard   ::when Paxil CR might be available again?   I went to drugstore.com and it seems that paxil cr is available. I was able to   add paxil cr to my shopping cart without getting a notice that it was   unavailable. Call a local pharmacy and inquire about paxil cr`s status.   http://www.drugstore.com/pharmacy/drugindex/rxsearch.asp?search=paxil+cr   Good luck with your upcoming pdoc appt! Let me know how it goes.   Jackie   ~*~I`m an angel! Honest <img src='http://sleepingdisorderfaq.com/wp-includes/images/smilies/icon_smile.gif' alt=':)' class='wp-smiley' />  The horns are just there to keep my halo up   straight~*~ </p>
<p>&#8211;  The charter is available at: http://readystump.algebra.com/~asapm </p>
</p>
<h4><strong>Response:</strong></h4></p>
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		<item>
		<title>SWSD (Shift work sleep Disorder) Question</title>
		<link>http://sleepingdisorderfaq.com/shift-work-sleep-disorder/swsd-shift-work-sleep-disorder-question-2359310.html</link>
		<comments>http://sleepingdisorderfaq.com/shift-work-sleep-disorder/swsd-shift-work-sleep-disorder-question-2359310.html#comments</comments>
		<pubDate>Tue, 14 Dec 2004 00:00:00 +0000</pubDate>
		<dc:creator>admin</dc:creator>
				<category><![CDATA[Shift Work Sleep Disorder]]></category>

		<guid isPermaLink="false">http://sleepingdisorderfaq.com/uncategorized/swsd-shift-work-sleep-disorder-question-2359310.html</guid>
		<description><![CDATA[Question:
Hello&#44;  I&#8217;m 22. I was delivering papers and Dj&#8217;ing late in the night for nearly  6 months. I&#8217;m now trying to get my circadian rythms back into a normal  day-time cycle for my new job and for college classes.  In other words.. I now sleep all day.. and am awake all [...]]]></description>
			<content:encoded><![CDATA[<h4><strong>Question:</strong></h4>
<p>Hello&#44;  I&#8217;m 22. I was delivering papers and Dj&#8217;ing late in the night for nearly  6 months. I&#8217;m now trying to get my circadian rythms back into a normal  day-time cycle for my new job and for college classes.  In other words.. I now sleep all day.. and am awake all night. This  isn&#8217;t insomnia by any means.. I sleep hard and well during they day&#44;  but it&#8217;s costing me job performance and productivity in my life. Does  anyone else experience this? Can anyone suggest ways to correct it? I  understand it isn&#8217;t fixable overnight since my body has adapted to the  lifestyle I was living&#44; but i&#8217;d like to get a start on making my life  change from night owl.. to early bird.  Thank you for your time and help.  Kind Regards&#44;  Backa**wards in S. Cali </p>
</p>
<h4><strong>Response:</strong></h4>
<p>light therapy can help with this  of course you will have to get UP at a reasonable hour to expose yourself to  the lights in order for the circadian rhythm to kick back to normal  so&#8230;&#8230;. stay up all night and then start the light therapy&#8230;. and stay up  all day and go to bed at the time that you want to go to sleep&#8230;&#8230; means  for one tiring day&#44; and a while using the light therapy to get up with&#8230;&#8230;  but it will pay off in dividends for you  kate  &lt;coolkid&#8230;@hotmail.com&gt; wrote in message </p>
<p>news:1103022974.356265.107670@f14g2000cwb.googlegroups.com&#8230;  &#8211; Hide quoted text &#8212; Show quoted text -&gt; Hello&#44;  &gt; I&#8217;m 22. I was delivering papers and Dj&#8217;ing late in the night for nearly  &gt; 6 months. I&#8217;m now trying to get my circadian rythms back into a normal  &gt; day-time cycle for my new job and for college classes.  &gt; In other words.. I now sleep all day.. and am awake all night. This  &gt; isn&#8217;t insomnia by any means.. I sleep hard and well during they day&#44;  &gt; but it&#8217;s costing me job performance and productivity in my life. Does  &gt; anyone else experience this? Can anyone suggest ways to correct it? I  &gt; understand it isn&#8217;t fixable overnight since my body has adapted to the  &gt; lifestyle I was living&#44; but i&#8217;d like to get a start on making my life  &gt; change from night owl.. to early bird.  &gt; Thank you for your time and help.  &gt; Kind Regards&#44;  &gt; Backa**wards in S. Cali  </p>
</p>
<h4><strong>Response:</strong></h4></p>
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		<title>MDs begin discussing modafinil (Provigil)</title>
		<link>http://sleepingdisorderfaq.com/shift-work-sleep-disorder/mds-begin-discussing-modafinil-provigil-2352916.html</link>
		<comments>http://sleepingdisorderfaq.com/shift-work-sleep-disorder/mds-begin-discussing-modafinil-provigil-2352916.html#comments</comments>
		<pubDate>Wed, 06 Nov 2002 00:00:00 +0000</pubDate>
		<dc:creator>admin</dc:creator>
				<category><![CDATA[Shift Work Sleep Disorder]]></category>

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		<description><![CDATA[Question:
Type A&#8217;s perk up over modafinil&#44; an anti-sleeping pill  Doctors be ready: A medication for sleep disorders is bound to attract  interest from people who are just plain sleepy.  By Susan J. Landers&#44; AMNews staff.  Nov. 11&#44; 2002.  &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212; &#8212;&#8211;  Washington &#8212; A surgeon awakens groggy after a restless [...]]]></description>
			<content:encoded><![CDATA[<h4><strong>Question:</strong></h4>
<p>Type A&#8217;s perk up over modafinil&#44; an anti-sleeping pill  Doctors be ready: A medication for sleep disorders is bound to attract  interest from people who are just plain sleepy.  By Susan J. Landers&#44; AMNews staff.  Nov. 11&#44; 2002.  &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212; &#8212;&#8211;  Washington &#8212; A surgeon awakens groggy after a restless night&#44; feeling  less than tip-top for a tricky&#44; 12-hour procedure. A shift worker  can&#8217;t cope with the circadian chaos caused by working when sleep is  called for. A Wall Street lawyer puts in the usual 14-hour day and a  night of socializing and must bounce back to make million-dollar  decisions in the morning.  All are sleep-deprived&#44; and all could seek modafinil&#44; a stimulant  marketed in the United States under the name Provigil by Cephalon  Inc.&#44; a biopharmaceutical company in West Chester&#44; Pa. Used in Europe  for several years&#44; it was approved in late 1998 by the Food and Drug  Administration for use by patients who have narcolepsy. But could this  drug also be the answer for which some of those Type A&#8217;s have been  looking?  So far the medication has an admirable safety record. As word of its  attributes spreads&#44; it could be tapped as a support system for  fast-paced lives &#8212; and become a topic between patients and primary  care physicians.  It is already prescribed off label for people with sleep apnea and  depression&#44; and studies have shown that it is effective for multiple  sclerosis patients with excessive sleepiness.  The military is interested in modafinil&#44; and a study at Fort Rucker in  Alabama found that the drug boosted the performance of sleep-deprived  helicopter pilots. But another study done at Walter Reed Army  Institute of Research&#44; Silver Spring&#44; Md.&#44; found that while modafinil  works&#44; so do six cups of coffee.  Meanwhile&#44; modafinil has become a big seller&#44; with its sales doubling&#44;  $72 million to $150 million&#44; from 2000 to 2001. The company is  sponsoring studies intended to broaden the drug&#8217;s appeal and further  boost sales.  Only a half-hour of medical school training is devoted to sleep  disorders.  In late October&#44; the company announced the results of its 12-week  randomized&#44; double-blind study of 209 patients with shift-work sleep  disorder showing that modafinil significantly improved wakefulness.  The results will be used to support Cephalon&#8217;s bid to expand FDA  approval of the drug&#8217;s use for this indication&#44; said Frank Baldino  Jr.&#44; PhD&#44; company chair and CEO. The disorder is recognized in the  International Classification of Sleep Disorders: Diagnostic and Coding  Manual and is also classified as a circadian rhythm disorder by the  American Psychiatric Assn.  But the inevitable question has arisen. If it works so well for people  with sleep disorders&#44; why not use it for people who are just plain  sleepy?  Not so fast&#44; specialists say. &quot;People have to understand&#44; this isn&#8217;t  better living through chemistry&#44;&quot; said Thomas Roth&#44; PhD&#44; director of  research at Henry Ford Medical Center in Detroit&#44; which participated  in Cephalon-sponsored studies of the drug.  While modafinil is a welcome treatment for patients with narcolepsy  and certain other sleep disorders&#44; its long-term use by healthy people  is not encouraged. &quot;I don&#8217;t think people could support using something  like modafinil long term in normal people based on what we know right  now&#44;&quot; said Meir Kryger&#44; MD&#44; director of the Sleep Disorders Center at  the University of Manitoba&#44; Canada.  &quot;I feel very nervous about giving someone a treatment for something  that is not a medical condition&#44; but is a lifestyle thing&#44;&quot; he added.  Dr. Kryger doesn&#8217;t prescribe modafinil for such patients.  But with the drug seemingly poised at the top of a slippery slope that  could well lead to its use as a so-called lifestyle drug&#44; physician  prescribing patterns are key.  What primary care physicians should know about modafinil is an  important issue&#44; said Karl Doghramji&#44; MD&#44; director of the Sleep  Disorders Center at Thomas Jefferson University Hospital in  Philadelphia.  &quot;If I correctly understand it&#44; the company&#8217;s future plans include the  possibility of making an initiative to primary care physicians&#44;&quot; he  said. And the entry of primary care physicians into the sleep disorder  picture would mean that many more patients would receive needed  treatment&#44; Dr. Doghramji said.  But with surveys showing that only about a half-hour of medical school  training is devoted to sleep disorders&#44; primary care physicians may  face a steep learning curve&#44; he noted.  &quot;When do you&#44; as a primary care physician&#44; decide this patient has X  disorder and go ahead and treat it&#44; and when do you send the patient  to a special center like a sleep disorders center?&quot; he asked. &quot;And if  you do send a patient to a center&#44; what do you do with the data you  receive?&quot;  Take it a case at a time  Decisions to use modafinil should be made on a patient-by-patient  basis&#44; said Neil B. Kavey&#44; MD&#44; director of the Sleep Disorders Center  at New York Presbyterian Hospital/Columbia Presbyterian Medical  Center.  While there will be some clear and proper uses for it&#44; others will be  a judgment call&#44; said Dr. Kavey&#44; who has prescribed the drug for  off-label uses. &quot;It&#8217;s easy with the surgeon who is dealing with  multiple traumas from accidents and who has to be up and up and up.  You&#8217;re going to give that surgeon Provigil.&quot;  Modafinil kept study subjects awake; so did six cups of coffee.  But most agree that physicians would be very careful about prescribing  modafinil solely to allow healthy patients to go for long periods  without sleep. &quot;I think most clinicians are very conservative in the  use of medications&#44;&quot; Dr. Roth said.  Safety is an issue&#44; he said. Despite its good record&#44; modafinil is a  medication&#44; he noted&#44; and it is intended for specific disorders. After  all&#44; &quot;do we give people diet pills so they can eat bacon burgers? Do  we give people Lipitor so they can eat yolks?&quot;  Carl E. Hunt&#44; MD&#44; agreed. &quot;There is no substitute for a good night&#8217;s  sleep on a regular basis&#44;&quot; said Dr. Hunt&#44; who directs the National  Center on Sleep Disorders Research&#44; part of the National Institutes of  Health.  The sleep center is fielding many questions regarding the use of  modafinil for patients who do not have narcolepsy but who are  chronically sleepy. &quot;But there are no data that suggest that would be  recommended or safe&#44;&quot; Dr. Hunt said.  Modafinil&#8217;s effect on such important physiologic benefits of sleep as  learning and memory&#44; mood and behavior&#44; appetite and resistance to  disease is unknown&#44; Dr. Hunt said.  The most common explanation for people being sleepy is they are simply  not getting enough sleep&#44; he said. In that population&#44; no sleep  medicine physician would recommend using modafinil because of the  concern about side effects. &quot;The price we pay for using it could be  much more serious than any possible benefit one might get&#44;&quot; Dr. Hunt  said.  &#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212; &#8212;&#8211;  ADDITIONAL INFORMATION:  The specifics  Provigil (modafinil): A central nervous system stimulant made by  Cephalon Inc. and approved in 1998  Indication: Helps people with narcolepsy stay awake  Market performance: Sales of modafinil doubled from $72 million in  2000 to $150 million in 2001  ==========  FAIR USE NOTICE: This posting contains copyrighted material the use  of which has not always been specifically authorized by the copyright  owner. We are making such material available in our efforts to advance  understanding of political&#44; human rights&#44; economic&#44; democracy&#44;  scientific&#44; and social justice issues&#44; etc. We believe this  constitutes a &quot;fair use&quot; of any such copyrighted material as provided  for in section 107 of the US Copyright Law. In accordance with Title  17 U.S.C. Section 107&#44; the material on this site is distributed  without profit to those who have expressed a prior interest in  receiving the included information for research and educational  purposes. For more information go to:  http://www.law.cornell.edu/uscode/17/107.shtml  If you wish to use copyrighted material from this posting for  purposes of your own that go beyond &quot;fair use&#44;&quot; you must obtain  permission from the copyright owner.  -dave  ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~  | &nbsp; &nbsp; &nbsp; &nbsp;Dave Jackson * http://www.AwakeInPhilly.org * Phila.&#44; PA.  + &nbsp; ~~eFax: 253-423-7208~~ &nbsp;* &nbsp;mailto:usenet_u&#8230;@UNICORNcomcast.net  | &nbsp; &nbsp; Remove the mythical creature from my email address to reply  | &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; Some make it happen&#44; some watch it happen&#44;  | &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;and some say&#44; &quot;What happened?&quot; &#8211; Unknown &nbsp;  ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ </p>
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<h4><strong>Response:</strong></h4>
<p>Interesting stuff.  My apnea is not really responding to CPAP treatment at this point in time&#44; and  my daytime fatigue levels have rendered me non-functional and on short-term  disability. I believe Provigil is my next option&#44; as wary as I am about  stimulants.  I can see a huge black market for this stuff&#44; though&#44; especially among the  party-hearty crowd. (Oh&#44; if they only knew how much energy they were already  blessed with!) </p>
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<h4><strong>Response:</strong></h4></p>
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