Xanax dosing schedule
Question:
writes: I am really curious about why your doc is afraid of the buprenorphine combined with benzo’s?
I can’t find much info on bup (asked on sci.med and sci.med.pharmacy, though), but the PDR mentions that there’ve been some reports of shock and respiratory collapse with combinations of buprenorphine and Valium. Nothing to do with substance abuse. Buprenorphine doesn’t affect the GABA system that benzo’s do, does it?? So, if there is no cross-interaction, there is obviously no worry for drug/drug interaction problems.
It’s a question of additive side effects: they’re both CNS depressants, though they have different mechanisms. Also remember that the different neurotransmitter systems are all in bed together, so a drug that has a direct effect on A may as a result have an indirect effect on B. (Think SSRIs and dopamine.) He is kind of insecure. He’s young, I think he’s only been out of residency a couple years. This has its advantages as well as disadvantages – he’s *very* up-to-date, his education is current, etc. (Also, of course, he’s cute.) He also seems kind of excited about trying this out. I think he thinks I’m an "interesting case." (LOL) Not too many doctors have prescribed opiates for depression/anxiety, so I can see how he would find it cool. We did discuss the possibility of ordering Temgesic from the UK or Mexico (he’s done same with moclobemide a few times, he says). It’s not available in Canada by any chance, is it? -elizabeth
Response:
writes: <polite snip We did discuss the possibility of ordering Temgesic from the UK or Mexico (he’s done same with moclobemide a few times, he says). It’s not available in Canada by any chance, is it? -elizabeth
Hi Elizabeth: This isn’t exactly the answer you where looking for….but I do have a question. Temgesic is the brand name of buprenorphine?? Well…here are some recent letter’s and research reports supporting some of the same detoxification and "Harm Reduction" models currently used in many European countries. The first is a letter by a doctor to the Canadian Medical Association Journal; the second is a Canadian government sponsored "white paper" (a report that recommends the government takes specific actions….usually end up becoming gov’t policy). They both mention buprenorphine in a positive light. Right now, though, it is just considered an "experimental" drug here in Canada (ie. have to get gov’t permission to take). Here are the articles: — Time for legalized distribution of illegal drugs? CMAJ 1997;157:1345 Re: "Needle exchange: Panacea or problem?" (CMAJ 1997;157[3]:275-7 [full text / r
